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| Mental Retardation Research Published In Nature | Thu, 05 Aug 2010 |
| Malfunction of a protein has been linked to a form of mental retardation that affects up to one out of every 500 males, says Nasser K. Yaghi, a Texas A&M University magna cum laude biology graduate who was selected to participate in a medical research project at Harvard that has been published in the journal Nature... | |
| New Epigenetic Player In Mental Retardation And Facial Birth Defects | Wed, 14 Jul 2010 |
| A subtle mutation affecting the epigenome - a set of dynamic factors that influence gene activity - may lead to an inherited form of mental retardation that affects boys, find researchers at Children's Hospital Boston. The disorder, which also involves cleft lip or cleft palate, appears to hinge on an enzyme working in a biological pathway that may offer several potential drug targets... | |
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| Novel Genes Associated With Risk For Oral Cleft Malformation Identified | Tue, 04 May 2010 |
| An international consortium of scientists, led by researchers at Johns Hopkins University has identified two genes that when altered are closely associated with cleft lip and/or cleft palate. Cleft lip and cleft palate are among the world's most common congenital malformations and occur in one in every 700 births... | |
| News From The Journal Of Clinical Investigation, April 26, 2010 | Tue, 27 Apr 2010 |
| NEUROBIOLOGY: Too hot to handle: how heat causes pain Our body detects heat above 43 degrees Celsius as painful. The main detector of noxious heat is the protein TRPV1 on pain-sensing sensory nerve cells. Exactly how TRPV1 sensitivity to heat is regulated has not been clearly determined... | |
| People With Facial Paralysis More Socially Adjusted Than Previously Thought | Tue, 20 Apr 2010 |
| A smile means happiness, a frown sadness, a raised brow surprise. Even when languages and cultures differ, people have this universal form of communication. But Moebius syndrome, a rare congenital condition causing facial paralysis, can rob people of this basic connection, affecting social interaction... | |
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| Team Approach Provides Better Care For Children With Cleft Lip And Palate | Sat, 13 Mar 2010 |
| Children with a cleft lip or cleft palate are more likely to receive recommended age-appropriate health care when that care is provided by an interdisciplinary team rather than an individual provider. In a study encompassing three states, Arkansas, Iowa and New York, 24% of participants were not receiving team care... | |
| Growth Factor Gene Shown To Be A Key To Cleft Palate | Wed, 03 Feb 2010 |
| Cleft palate has been linked to dozens of genes. During their investigation of one of these genes, researchers at Washington University School of Medicine in St. Louis were surprised to find that cleft palate occurs both when the gene is more active and when it is less active than normal... | |
| Growth Factor Gene Shown To Be A Key To Cleft Palate | Wed, 03 Feb 2010 |
| Cleft palate has been linked to dozens of genes. During their investigation of one of these genes, researchers at Washington University School of Medicine in St. Louis were surprised to find that cleft palate occurs both when the gene is more active and when it is less active than normal... | |
| Pitt Researcher To Co-Direct National Consortium On Facial Birth Defects | Wed, 18 Nov 2009 |
| Researchers at the University of Pittsburgh and the University of Iowa will lead a $9 million, five-year initiative to study the cause of facial birth defects. The FaceBase Consortium will create an encyclopedic database of how the faces of children develop and what goes wrong to cause malformations... | |
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| FaceBase Consortium Launched By NIDCR | Thu, 08 Oct 2009 |
| Although about half of all birth defects involve the face and skull, scientists remain unclear about why most occur. To help families at risk for these conditions, what's needed is a comprehensive and systematic understanding of how the faces of healthy children develop and what goes awry to cause common malformations... | |
| Titan Announces Award Of NIH Grant For Probuphine(R) Clinical Development | Sun, 04 Oct 2009 |
| Titan Pharmaceuticals, Inc (Pink Sheets:TTNP) announced that the National Institutes of Health (NIH) has awarded a Research and Research Infrastructure Grand Opportunities grant to the company through the American Reinvestment and Recovery Act of 2009 (ARRA). The two year grant for Probuphine clinical development is expected to provide approximately $7... | |
| PCE Exposure Increases Risk Of Birth Defects | Thu, 24 Sep 2009 |
| Exposure to tetrachloroethylene (also known as perchlorethylene, PCE) may cause congenital birth defects. A study of expectant women exposed to PCE in drinking water, published in BioMed Central's open access journal Environmental Health, found an increased risk of oral clefts and neural tube defects in their children... | |
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| Bonn Scientists Discover Gene Locus Associated With Cleft Lip And Palate | Mon, 09 Mar 2009 |
| Comparing 500,000 snippets of human DNA put scientists from the University of Bonn on the right track. A genetic variant on chromosome 8 occurs with significantly higher frequency in people with cleft lip and palate than in the control group. The results are to be published in the forthcoming issue of the journal Nature Genetics... | |
| Increased Prevalence Of Left-Handedness In Children With Facial Development Disorder | Wed, 04 Mar 2009 |
| A new study by physician researchers from Hasbro Children's Hospital and Children's Hospital Boston has identified an increased prevalence in left-handedness in children with a congenital disorder known as hemifacial microsomia (HFM). The study was published in the March 2009 edition of the Journal of Craniofacial Surgery. Overall, ten percent of the population is left-handed... | |
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| Advancement In Tissue Engineering Promotes Oral Wound Healing | Wed, 04 Feb 2009 |
| Oral tissue engineering for transplantation to aid wound healing in mouth (oral cavity) reconstruction has taken a significant step forward with a Netherlands-based research team's successful development of a gum tissue (gingival) substitute that can be used for reconstruction in the oral cavity. Their work was reported in the current issue of Cell Transplantation (17:10/11)... | |
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| Oral Clefts And First Trimester Smoking Linked | Wed, 24 Dec 2008 |
| Smoking during the first trimester of pregnancy is clearly linked with an increased risk of cleft lip in newborns. Genes that play a role in detoxification of cigarette smoke do not appear to be involved. This is shown in a new study published in the journal Epidemiology. Oral clefts are one of the most common birth defects... | |
| Increased Risk Of Birth Defects Linked To Maternal Smoking | Wed, 05 Nov 2008 |
| Babies whose mothers smoked during pregnancy were more than twice as likely to have a cleft palate or lip as those whose mothers didn't, according to research results released today. Although the study confirms earlier findings, it is unique because it did not rely on women's self-reported smoking habits during pregnancy... | |
| Genetic Variant Plays Role In Cleft Lip | Tue, 07 Oct 2008 |
| University of Iowa researchers and collaborators have found, in a previously identified gene, a variation that likely contributes to one in five cases of isolated cleft lip. It is the first time a genetic variant has been associated with cleft lip alone, rather than both cleft lip and palate... | |
| Susceptibility To Cleft Palate Revealed By Genetic Profile | Tue, 16 Sep 2008 |
| For the first time, researchers from the University of Pittsburgh School of Dental Medicine have identified a series of genetic mutations that appear to be linked to significant risk for cleft palate and other dental abnormalities... | |
