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| Malignancy Of Lung Cancer Determined By Micro-RNA | Fri, 10 Sep 2010 |
| Cancer becomes life-threatening when tumor cells start leaving their primary site. They travel through the lymph and blood streams to other tissues where they grow into metastases. This transition to malignancy is associated with characteristic changes in the cancer cells. The activity of several genes is reprogrammed and, thus, the production of proteins anchoring cells to a tissue is reduced... | |
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| Potential New Drug For Neurodegenerative Disease | Fri, 10 Sep 2010 |
| Scientists have discovered a small molecule that helps human cells get rid of the misfolded, disfigured proteins implicated in Alzheimer's disease and other neurodegenerative ailments. This potential drug could have applications for other conditions as well... | |
| Microbial Sex And Virulence | Fri, 10 Sep 2010 |
| Two opportunistic pathogens that were once thought to be very different have evolved some sexual reproduction and disease-causing habits that are not only similar but also suggest that in the microbial world sex and virulence are closely linked, according to a review published this week in the online journal mBio?... | |
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| Molecular Gatekeeper Of Arthritis Identified | Fri, 10 Sep 2010 |
| Elimination of a molecular gatekeeper leads to the development of arthritis in mice, scientists report in a study published in The Journal of Experimental Medicine. The newly discovered gatekeeper is a protein that determines the fate - survival or death - of damaging cells that mistakenly attack the body's own tissues and lead to autoimmune disorders such as arthritis... | |
| Key Pharmacogenomics Resource Expanded By NIH | Thu, 09 Sep 2010 |
| To help advance research on how genes affect responses to medicines, the National Institutes of Health is spending $15 million over five years to expand a key resource, the Pharmacogenomics Knowledge Base (PharmGKB). The goal of pharmacogenomics is to use information about a patient's genetic make-up to optimize his or her medical treatment. As the field has grown, so has PharmGKB... | |
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| Why Chromosomes Never Tie Their Shoelaces | Thu, 09 Sep 2010 |
| In the latest issue of the journal Nature, Miguel Godinho Ferreira, Principal Investigator at the Instituto Gulbenkian de Ciência (IGC) in Portugal, lead a team of researchers to shed light on a paradox that has puzzled biologists since the discovery of telomeres, the protective tips of chromosomes: while broken chromosome ends generated by DNA damage (such as radiation or cig... | |
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| Researchers Identify Genes Tied To Deadliest Ovarian Cancers | Thu, 09 Sep 2010 |
| Scientists at the Johns Hopkins Kimmel Cancer Center have identified two genes whose mutations appear to be linked to ovarian clear cell carcinoma, one of the most aggressive forms of ovarian cancer. Clear cell carcinoma is generally resistant to standard therapy... | |
| NIH Ramps Up Human Microbiome Project | Thu, 09 Sep 2010 |
| The National Institutes of Health today announced it has awarded approximately $42 million to expand the scope of eight demonstration projects designed to link changes in the human microbiome to health and disease. The funds will also support investigators to develop innovative technologies to improve the identification and characterization of microbial communities of the human microbiome... | |
| Does The Impact Of Psychological Trauma Cross Generations? | Thu, 09 Sep 2010 |
| In groups with high rates of posttraumatic stress disorder (PTSD), such as the survivors of the Nazi Death Camps, the adjustment problems of their children, the so-called "Second Generation", have received attention by researchers. Studies suggested that some symptoms or personality traits associated with PTSD may be more common in the Second Generation than the general population... | |
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| UC San Diego To Lead New Pharmacogenomics Project | Wed, 08 Sep 2010 |
| An international team, led by University of California, San Diego School of Medicine researchers, has been awarded a $6.5 million grant from the National Institutes of Health (NIH) to study the pharmacogenomics of a key mood-stabilizing drug used to treat bipolar disorder... | |
| NIH Awards Nearly $10 Million To UF Pharmacogenomics Researcher | Wed, 08 Sep 2010 |
| A University of Florida genetics researcher has received $9.8 million to further a national effort to use genetic data to more effectively pinpoint which medications and treatments are best for individual patients. Julie A. Johnson, Pharm.D... | |
| Consumers Have Concerns About Home Genetic Tests | Wed, 08 Sep 2010 |
| One-half of people using direct-to-consumer (DTC) personal genetic risk tests express concerns about testing-yet more than 80 percent want to know their risk even for non-preventable genetic diseases, according to a study in the September Genetics in Medicine, the official peer-reviewed journal of The American College of Medical Genetics (ACMG)... | |
| Explaining An Important Genetic Cardiovascular Risk Factor | Wed, 08 Sep 2010 |
| New findings reported in the September issue of Cell Metabolism, a Cell Press publication, appear to explain why people who carry specific and common versions of a single gene are more likely to have high cholesterol and to suffer a heart attack. Studies in mice show that the gene, known as sortilin (SORT1), controls the release of LDL (a.k.a... | |
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| St. Jude Researcher Receives Grant To Focus On Cancer Pharmacogenomics In Children | Wed, 08 Sep 2010 |
| With its new expansion of the Pharmacogenomics Research Network (PGRN), the National Institutes of Health (NIH) awarded St. Jude Children's Research Hospital a prestigious grant to focus on anticancer agent research in children. The five-year, $8.6 million grant is titled "PAAR4Kids Pharmacogenomics of Anticancer Agents Research in Children." "We've been part of the PGRN for 10 years... | |
| Sequencing Of First Irish Genome | Wed, 08 Sep 2010 |
| The first entire genome of an Irish individual has been sequenced. The sequence is reported in BioMed Central's open access journal, Genome Biology and provides insight into the evolutionary history of this distinct lineage... | |
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